This website provides an interactive tool designed to use serum or plasma measures of neurofilament light chain in patients with cerebrovascular disease to predict the likelihood of a stroke diagnosis and the probability of the timing of their stroke based on the biomarker level.

In Sanchez et al. (2021), we developed a composite data set of all available studies using serum or plasma neurofilament light chain as a biomarker for patients with acute stroke and/or chronic cerebrovascular disease. The composite dataset is available as Supplementary data associated with Sanchez et al. while the contributing studies are available as pdf by visiting: osf.io/j469n

To use the interactive tool, input a measured serum or plasma values of neurofilament light chain from a patient or research subject measured using the Quanterix® SIMOA platform. Please note, the range is limited from 5 pg/mL to 5000 pg/mL. Measured values above 5000 pg/mL should be entered as 5000 as the results will not vary above this upper limit threshold. The output will include the probability of a stroke diagnosis as well as a likelihood ratio for a stroke diagnosis. Patients/subjects with TIA may also have elevated serum/plasma neurofilament light chain values however this model cannot reliably distinguish stroke vs. TIA. This is an unvalidated research tool, clinical judgement should be utilized at all times.